Sperm morphology issues have to do with the size and shape of the sperm. Although this problem can cause some severe Causes of Infertility: Sperm Morphology. Abnormal sperm morphology causes male infertility and it's one of the reasons why some couples cannot conceive. Most infertile men have a low sperm count, also called Oligospermia. Low sperm count is often associated with poor sperm motility. Pregnancy IVF. Overcoming Infertility. Menu Home; Abnormal sperm morphology is one cause of male infertility. When looking at sperm under the microscope.