What are the premature ageing syndromes? Premature ageing syndromes, also known as progeria, include two very rare inherited conditions, Hutchinson-Gilford syndrome and Werner syndrome. a premature aging disorder presenting sclerodermalike skin changes, bilateral juvenile cataracts, progeria, hypogonadism, and diabetes mellitus; autosomal recessive inheritance, caused by mutation in the WRN gene, which encodes a helicase protein on chromosome 8p. Werner syndrome is extremely rare syndrome, which was names after C.W. Otto Werner, a German physician who described the syndrome in in his thesis. Werner syndrome is a hereditary condition due to gene mutation of chromosome 8 encoding Werner’s protein.